Original Article

The value of 25 (OH) and 1,25 (OH) vitamin D serum levels in newly diagnosed or on diet adult celiac patients: A case- control study


Ahmet Uyanikoglu1, Cigdem Cindioglu2, Atilla Ciftci2, Ismail Koyuncu3, Mehmet Ali Eren4

1Department of Gastroenterology, Harran University Faculty of Medicine, Sanliurfa, Turkey
2Department of Internal Medicine, Harran University Faculty of Medicine, Sanliurfa, Turkey
3Department of Biochemistry, Harran University Faculty of Medicine, Sanliurfa, Turkey
4Department of Endocrinology, Harran University Faculty of Medicine, Sanliurfa, Turkey


Abstract


Background: The levels of 25-hydroxy (OH) vitamin D and 1.25 (OH) vitamin D were investigated in newly diagnosed celiac disease (CD), CD on diet, and control subjects.
Methods: Patients with newly diagnosed CD (n= 40) or CD on gluten-free diet (n=40) and healthy controls (n= 40) were included. CD was diagnosed with clinical features, serological and histopathological methods. Vitamin D levels were measured by LC-MS/MS device (Shimadzu 8045).
Results: The 25-hydroxy (OH) vitamin D levels of CD patients on a diet (18.93 +- 12.4) were significantly lower than newly diagnosed CD patients (31.31 +- 22.9) and controls (21.95+-17.09) (p<0.01 and p<0.05, respectively). The 1,25 (OH) vitamin D levels of the CD patients on diet (129.82+-84.42) were significantly lower than newly diagnosed CD (134.33 +- 44.35) (p< 0.05) but; higher than the control group (118.43+- 48) (p< 0.001). Also, the 25 (OH) and 1,25 (OH) vitamin D levels were lower in newly diagnosed CD than in the control group but this did not reach statistical significance (p>0.40 and p>0.79, respectively).
Conclusions: The vitamin D level in CD patients should be measured at the time of diagnosis and monitored with dietary and nutritional recommendations to maintain adequate vitamin D levels.

Keywords: 1,25 (OH) vitamin D; 25 (OH) vitamin D; celiac disease