Case Report

Glucose-lowering efficacy of Xultophy with low doses by FreeStyle Libre as continuous glucose monitoring (CGM)

Takafumi Kawata1, Hiroshi Bando2,3, Yoshinobu Kato1, Yoshikane Kato1, Setsuko Kanazawa1, Etsuko Sueki1, Hiroe Kanagawa1, Atsuko Kawahito1, Aya Aihara1, Ayako Fujii1

1Kanaiso Hospital, Tokushima, Japan
2Tokushima University/Medical Research, Tokushima, Japan
3Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan


The daily profile of blood glucose can be detected by continuous glucose monitoring (CGM) using FreeStyle Libre. The case was a 51-year-old female with type 2 diabetes mellitus (T2DM) for uncontrolled glucose variability as HbA1c 10.3%. During CGM measurement, diabetic treatment was changed from multiple daily insulin injections (MDI) to Xultophy (insulin degludec and liraglutide). Xultophy starting from 10 to 18 doses has brought the improvement of glucose variability, such as decreased pre-prandial glucose from 268 mg/dL to 101 mg/dL. Consequently, detailed data of glucose variability on Xultophy using CGM would be beneficial and become some reference for further clinical diabetic research.

Keywords: continuous glucose monitoring; FreeStyle Libre; Xultophy