Original Article

The morphology and neuronal-glial correlations of the spinal cord posterior horns of human embryos


Sergii Viktorovych Vernygorodskyi1, Volodymyr Semenovych Shkolnikov2, Svitlana Oleksandrivna Prykhodko2

1Department of Pathological Anatomy, Vinnytsia National Pirogov Memorial Medical University, Vinnytsia, Ukraine
2Department of Pathological Anatomy, Vinnytsia National Pirogov Memorial Medical University, Vinnytsia, Ukraine


Abstract


Background: This research examines the morphology and neuronal-glial correlations of human spinal cord posterior horns formations in the embryonic period of ontogenesis.
Methods: 29 human embryos with a gestational age of 5-8 weeks were involved in the investigation, without visible damages and abnormalities in the development of the brain and spinal cord. Anatomical, histological, immunohistochemical, morphometric and statistical methods were used.
Results: The glial index in 5-6-week human embryos in the posterior horns of cervical segments made 1.6, in thoracic segments ? 1.4, in lumbar segments ? 1.5, and in sacral segments ? 1.3. In 6-7-week human embryos, on the lateral surfaces of the neural tube between alar and basal plates, the sulcus limitans is still preserved. The glial index in 7-8-week human embryos of posterior horns of cervical segments made 1.7, in thoracic segments ? 1.5, in lumbar segments 1.6, and in sacral segments ? 1.4. In 7-8-week embryos, the basal and alar plates are not distinguished anymore, that is why the terminal sulcus is absent.
Conclusions: The glial index of the posterior horns of all the segments along with the spinal cord increases by the 6th-7th week, and remains unchanged by the beginning of the gestational period (before the 8th week).

Keywords: embryos; neuronal-glial correlations; posterior horns; spinal cord