Original Article

The effect of hydroxychloroquine and azithromycin combination treatment on T peak-end, QT, corrected QT intervals and T peak-end/QT and T peak-end/corrected QT ratios in patients with COVID-19


Ayhan Cosgun1, Huseyin Oren2, Mustafa Hamidullah Turkkani3

1Department of Cardiology, Dr. Nafiz Korez Sincan State Hospital, Ankara, Turkey
2Department of Cardiology, Ankara City Hospital, Ankara, Turkey
3Department of Chest Disease, Dr. Nafiz Korez Sincan State Hospital, Ankara, Turkey


Abstract


Background: Hydroxychloroquine and azithromycin are frequently used agents in the treatment of COVID-19. We aimed to investigate the effect of hydroxychloroquine and azithromycin combination therapy on repolarization markers of malignant ventricular arrhythmia.
Methods: A total of 107 patients, 54 males, and 53 females, who was positive for COVID-19 in terms of the Polymerase Chain Reaction test (PCR) and had typical viral pneumonia on thoracic computed tomography included in the study. These patients were given a combination of 5-day hydroxychloroquine and azithromycin therapy. Electrocardiograms (ECG) were taken before and after this treatment. T peak-end (Tp-e) interval, QT interval, corrected QT (QTc) interval, Tp-e / QT, and Tp-e / QTc values were calculated in the recorded ECGs.
Results: Tp-e, QT, QTc intervals, and Tp-e / QT and Tp-e / QTc ratios increased significantly after treatment in both men and women compared to before the treatment.
Conclusions: Superficial ECG markers of malignant ventricular arrhythmias were significantly increased in both men and women receiving hydroxychloroquine and azithromycin combination treatment for COVID-19.

Keywords: azithromycin; COVID-19; T peak-end/corrected QT; T peak-end interval; T peak-end/QT