Case Report

Transiently elevated parathyroid hormone-related peptide level associated with hypercalcemia and worsening renal insufficiency

Run Yu

Division of Endocrinology, UCLA David Geffen School of Medicine, Los Angeles, California, USA


An elderly female patient with multiple potential causes of hypercalcemia is described here. Transient hypercalcemia and elevation of parathyroid hormone-related peptide (PTHrp) level were found during a period of worsening renal insufficiency, both calcium and PTHrp levels returned to normal after renal function improved. The patient had no evidence of malignancy. This case suggests that PTHrp level may be elevated in worsening renal insufficiency in some patients and elevated PTHrp level does not always indicate malignancy in patients with hypercalcemia.

Keywords: hypercalcemia, malignancy, parathyroid hormone-related peptide, renal insufficiency