Review Article

Vagus nerve stimulation in neurological diseases

Arda Kaan Uner1, Furkan Gozumoglu1, Enes Akyuz2

1Yozgat Bozok University Medical Faculty, Yozgat, Turkey
2Department of Biophysics, Yozgat Bozok University Medical Faculty, Yozgat, Turkey


Evidence from clinical and experimental research suggests that neurological diseases may affect the autonomic nervous system. Vagus nerve, the main component of the parasympathetic nervous system, provides the regulation of parasympathetic effects on the smooth muscle of the upper respiratory tract, gastrointestinal tract and heart. It has been used in the treatment of epilepsy and depression for years. In recent years, it has been showed that vagus nerve stimulation (VNS) can also be used in the treatment of Alzheimer's disease, Parkinson's disease, migraine and other disorders. Thus, it is crucial to understand the peripheral anatomy and physiology of the vagus nerve and how VNS reduces or eliminates these diseases. The molecular mechanism beyond this method needs to be elucidated with further studies. Therefore, in this review, it is planned to investigate the role of VNS method in neurological diseases.

Keywords: epilepsy, multiple sclerosis, neurology, vagus nerve stimulation