Relation of monocyte-to-HDL-cholesterol ratio with prognosis in patients with pulmonary embolismIdris Kirhan1, Iclal Hocanli2
1Department of Internal Medicine, Harran University, School of Medicine, Sanliurfa, Turkey
2Department of Thoracic Diseases, Harran University, School of Medicine, Sanliurfa, Turkey
International Medicine 2020; 2(1): 61-66 | DOI: 10.5455/im.84054 PDF
Background: Pulmonary embolism is a thromboembolic disease with high rates of morbidity and mortality. Monocyte-to-HDL- cholesterol ratio (MHR) can show the inflammatory status of patients. The objective of this study was to investigate the relationship of monocyte-to-HDL-cholesterol ratio, which is a new marker in predicting the prognosis of cardiovascular diseases, with prognosis and Pulmonary Embolism Severity Index (PESI) test in patients with pulmonary embolism.
Methods: Patients followed-up with the diagnosis of pulmonary embolism in our hospital between January 2016 and December 2018 were included in this study. Patients’ demographic data such as age and gender, vital findings, hemogram outcomes at admission, lipid profiles, liver function tests, renal function tests, electrolyte values and cardiac markers were recorded and analyzed. Patients’ pulmonary embolism (PE) clinical classes were determined and PESI test values were calculated. The correlations between monocyte- to-HDL-cholesterol ratio, PE severity and PESI test were analyzed.
Results: A total of 50 patients followed up in our hospital due to PE were included in the study. Of all patients 8% (n=4) were diagnosed with massive, 32% (n=16) sub-massive and 60% (n=30) non-massive PE. There was a positive correlation between MHR and PE severity, and MHR and PESI index, although these correlations were not statistically significant (r=0.011, p=0.940; r=0.043, p=0.767). Of all patients included in this study, one patient (2%) died in the hospital and 49 patients (98%) were discharged with recovery.
Conclusions: Although there were positive correlations between monocyte-to-HDL-cholesterol ratio, which is an inexpensive marker easily available in all centers, and the severity of acute pulmonary embolism and PESI test, these correlations were not statistically significant. Monocyte-to-HDL- cholesterol ratio may not be related to PE, however, further longitudinal studies are needed to clarify this finding.
Keywords: HDL, monocytes, pulmonary embolism