Glucose variability for a short period of low carbohydrate diet in diabetic patients with possible latent autoimmune diabetes in adults
Hiroshi Bando1,2, Koji Ebe2,3, Tetsuo Muneta2,4, Masahiro Bando5, Yoshikazu Yonei6
1Medical Research, Tokushima University, Tokushima, Japan
2Japan Low Carbohydrate Diet Promotion Association, Kyoto, Japan
3Takao Hospital, Kyoto, Japan
4Muneta Maternity Clinic, Chiba, Japan
5Department of Gastroenterology and Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
6Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, Japan
International Medicine 2019; 1(3): 124-133 | DOI: 10.5455/im.302644275 PDF
Background: Authors have continued research for meal tolerance test (MTT) by calorie restriction diet (CRD) and low carbohydrate diet (LCD), besides M value and glucose variability.
Methods: Subjects were 38 patients of two groups. Group-1 has 19 patients (57.6±12.9 years) with type 2 diabetes mellitus (T2DM) and positive glutamic acid decarboxylase antibody (GADA), which is possible to latent autoimmune diabetes in adults (LADA). Group-2 has recruited 19 cases with T2DM and negative GADA, who showed age, sex, glucose variability-matched subjects. They were given CRD on day 1-2, and LCD day 3-14, and biomarkers were compared between Group-1 and Group-2.
Results: Average values of the daily profile of blood glucose on day2(CRD)/day4(LCD) in Group-1 vs 2 were studied. Obtained data were 202/148 mg/dL vs 205/143 mg/dL, respectively with similarity. However, M value showed 174/58 vs 179/22, respectively with difference. There were significant correlations of M value between day2 and day4 in Group-1 vs Group-2. Further, both showed contrast tendency, associated with wide distribution vs narrow distribution, respectively.
Conclusions: These results suggested that Group-1 with positive GADA may have insufficient pancreas secretion compared with that of Group-2, and these data may become a basal reference for future study of LADA.
Keywords: calorie restricted diet (CRD), glutamic acid decarboxylase (GAD), latent autoimmune diabetes in adults (LADA), low-carbohydrate diet (LCD)