Year: 2019 Vol: 1 Issue: 5


  • International Medicine
  • Worldwide Medicine
  • International Medicine

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Relationship of mutation in adhesion molecules and cytokeratins with hair follicle diseases

Laura Silva1, Ricardo Hsieh2, Ricardo Romiti3, Alessandra Anzai3, Bruno Rocha1, Silvia Lourenço3, Neusa Valente4,5, Juliana Fernandes1
1Department of Dermatology, Professor Edgar Santos School Hospital Complex, The Federal University of Bahia, Salvador, Brazil
2Institute of Tropical Medicine of São Paulo, The University of São Paulo, São Paulo, Brazil
3Department of Dermatology, University of São Paulo Medical School, The University of São Paulo, São Paulo, Brazil
4Department of Stomatology, School of Dentistry, The University of São Paulo, São Paulo, Brazil
5Department of Dermatology, Hospital of the Public Server of the State of São Paulo, São Paulo, Brazil

International Medicine 2019; 1(5): 280-285 | DOI: 10.5455/im.54631      PDF


Abstract


Adhesion molecules and cytokeratins are essential for the development of hair follicles and their maintenance. These molecules seem to be responsible for the follicular germ downgrowth and signaling with mesenchymal cells for the correct development of hair follicles. In adulthood, changes in their functions are related to numerous pathologies that lead to hair shaft disorders and cicatricial and non-cicatricial alopecia. This work reviews the main adhesion molecules: cadherins, integrins and cytokeratins and their relationship with hair follicle pathologies.

Keywords: cytokeratin, hair diseases, hair follicle, monilethrix, vascular cell adhesion molecule

International Medicine

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