A novel mutation in the GRIN2A gene associated with autism spectrum disorderChen Yan1, Lanisha Fuller2, Richard A. Prayson2
1Department of Neurology, Cleveland Clinic, Cleveland, Ohio, USA
2Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
International Medicine 2020; 2(2): 147-149 | DOI: 10.5455/im.78381 PDF
Hepatocellular carcinoma usually metastasizes within the liver. Extrahepatic sites are less common but most frequently involve regional lymph nodes, lungs, adrenals and bones. Metastatic hepatocellular carcinoma to the skull is an uncommon occurrence with only a few case reports documented in the literature. We report a case of metastatic hepatocellular carcinoma to the clivus in a 67-year-old male who presented with headache, vertical diplopia, left ptosis and hypopituitarism.
Keywords: bone, hepatocellular carcinoma, hypopituitarism, metastasis, skull